Since its creation in 2011, the Canadian Network for Observational Drug Effect Studies (CNODES) has built a network of over 100 scientists to ensure the safety and effectiveness of drugs for Canadians. CNODES has obtained access to administrative healthcare data on millions of medication users across Canada and internationally. CNODES uses state of the art methods of observational research, as well as rapid-response studies using semi-automated tools and a common data model (CDM) for standardized analyses.
Current Publications
Risk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States
Clin Epidemiol. 2024 Feb 10;16:71-89.
Prescription ranitidine use and population exposure in 6 Canadian provinces, 1996 to 2019: a serial cross-sectional analysis
CMAJ Open. 2023;11(6):E1033-E1040.
Validity of diagnoses of SARS-CoV-2 infection in Canadian administrative health data: a multiprovince, population-based cohort study
CMAJ Open. 2023;11(5):E790-E798.
Hydrochlorothiazide use and risk of keratinocyte carcinoma and melanoma: A multisite population-based cohort study
J Am Acad Dermatol. 2023;89(2):243-253.
Project Findings
Risk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States
Natural coagulopathy and characteristics of its treatment in COVID-19 patients
Prescription ranitidine use and population exposure in 6 Canadian provinces, 1996 to 2019: a serial cross-sectional analysis
A total of 4.1 million prescriptions of ranitidine were dispensed across Canada from 1996-2019
Validity of diagnoses of SARS-CoV-2 infection in Canadian administrative health data: a multiprovince, population-based cohort study
Our findings support the use of inpatient and emergency department data as alternatives to laboratory test to identify COVID-19 cases
Hydrochlorothiazide use and risk of keratinocyte carcinoma and melanoma: A multisite population-based cohort study
Increased risks of skin cancer were observed with long-term use and higher cumulative doses of hydrochlorothiazide